Table 5.

Combined analysis of the allele frequencies of Xq28 genetic variants accordingly with pulmonary fibrosis in the study cohorts from Spain, Germany, The Netherlands and UK

rs#	Gene	Comparison	N	MAF (%)	M-H Allele test
					p Value*	OR (95% CI)†***
rs1059702	IRAK1	PF+ versus controls	461/2043	18.33/14.46	8.46E-03‡	1.30 (1.07 to 1.58)
		PF+ versus PF−	461/1149	18.33/15.54	0.025	1.26 (1.03 to 1.55)
rs17435	MECP2	PF+ versus controls	481/2035	22.66/18.72	0.015§	1.24 (1.04 to 1.48)
		PF+ versus PF−	481/1151	22.66/21.33	0.346	1.09 (0.91 to 1.31)

MAF, minor allele frequency; M-H, Mantel–Haenszel test under fixed effect; PF+, patients with pulmonary fibrosis; PF−, patients without pulmonary fibrosis.

^*All p values have been calculated for the allelic model.

^†OR for the minor allele.

^‡P_FDR=0.039.

^§P_FDR=0.039.