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Effects of CaV1.2 channel inhibition on exercise-mediated coronary vasodilation. a Inhibition of CaV1.2 channels with nifedipine did not decrease coronary vascular resistance in lean swine. b Nifedipine significantly reduced coronary vascular resistance in obese swine at rest and during exercise. Administration of nifedipine produced a significant upward shift in the slope relationship between coronary blood flow and MVO2 in obese (d) but not lean swine (c). *P < 0.05 vs. control
