Table 1.
Static Histomorphometry measures for each group are shown, Mean ± SD across animals within a group, 95% CI (5th, 95th).
| Measurement | SHAM (n=5) |
OVX (n=5) |
OVX+Ral (n=6) |
OVX+Ris (n=6) |
|---|---|---|---|---|
| Bone volume fraction (BV/TV, %) | 31.18±6.99 (22.50, 39.86)b | 20.18±4.08 (15.12, 25.24) | 25.68±5.92 (19.47, 31.90) | 26.05±3.01 (22.89, 29.21) |
| Bone-specific surface (BS/BV, mm−1) | 9.58±1.65 (7.53, 11.63)b | 6.98±1.11 (5.60, 8.36) | 9.03±1.18 (7.80, 10.27) | 8.38±0.76 (7.59, 9.18) |
| Trabecular thickness (Tb.Th, µm) | 87.52±7.57 (78.13, 96.92) | 76.14±3.20 (72.17, 80.12) | 75.13±14.58 (59.83, 90.43) | 83.59±8.83 (74.33, 92.85) |
| Trabecular separation (Tb.Sp, µm) | 243.01±62.92 (164.89, 321.14) | 344.83±38.32 (297.25, 392.42) | 228.51±30.29 (196.72, 260.29)b | 268.74±41.10 (225.61, 311.87) |
| Structural modeling index (SMI) | 1.16±0.27 (0.82, 1.50) | 1.47±0.37 (1.02, 1.93) | 1.48±0.34 (1.12, 1.83) | 1.44±0.11 (1.33, 1.56) |
| Degree of anisotropy (DA) | 0.68±0.12 (0.53, 0.83) | 0.65±0.08 (0.55, 0.75) | 0.72±0.06 (0.65, 0.79) | 0.67±0.12 (0.54, 0.80) |
| *Eroded surface (ES/BS, %) | 6.17±0.85 (5.12, 7.23) | 8.55±1.11 (7.17, 9.93) | 5.26±2.00 (3.16, 7.35)b | 5.06±1.41 (3.58, 6.54)b |
| †Median Maximum Cavity Depth (Cv.De, µm) | 23.66±1.87 (21.34, 25.97) | 22.88±3.69 (18.30, 27.47) | 14.96±2.30 (12.55, 17.38)ab | 14.94±2.70 (12.11, 17.77)ab |
| †Median Mean Cavity Depth (µm) | 3.76±0.42 (3.23, 4.28) | 3.20±0.88 (2.11, 4.29) | 2.38±0.47 (1.89, 2.87)a | 1.82±0.44 (1.36, 2.28)ab |
| †Median Cavity Surface Area (BS/Cv, 103 µm2) | 17.99±2.33 (15.11, 20.88) | 19.76±3.02 (16.01, 23.51) | 9.59±2.24 (7.24, 11.94)ab | 8.55±2.17 (6.28, 10.82)ab |
| †Median Cavity Volume (Cv.V, 103 µm3) | 31.49±5.18 (25.06, 37.92) | 33.92±5.87 (26.63, 41.21) | 17.73±3.96 (13.58, 21.89)ab | 15.44±3.32 (11.95, 18.92)ab |
*
Measured in two-dimensions using line intersection
†
Median of 8–32 cavities within a specimen
a
p<0.05 vs SHAM group
b
p<0.05 vs OVX group