Table 2.
Dynamic bone histomorphometry measures are shown for each group, Mean ± SD, 95% CI (5th, 95th).
| Measurement | SHAM (n=5) | OVX (n=5) | OVX+Ral (n=6) | OVX+Ris (n=6) |
|---|---|---|---|---|
| Double-labeled surface (dLS/BS, %) | 9.33±0.40 (8.84, 9.82) | 12.51±4.32 (7.14, 17.88) | 8.52±2.24 (6.17, 10.88) | 5.16±1.83 (3.24, 7.09)b |
| Mineralizing surface (MS/BS, %) | 11.45±0.76 (10.50, 12.39) | 13.89±4.61 (8.17, 19.62) | 10.38±2.71 (7.54, 13.22) | 8.14±1.98 (6.06, 10.22)b |
| Single-labeled surface (sLS/BS, %) | 4.23±2.19 (1.51, 6.95) | 2.75±1.11 (1.38, 4.13) | 3.71±2.26 (1.34, 6.08) | 6.06±1.94 (4.02, 8.10) |
| No. of double-labeled formation events (N.dL.Ev) | 59.20±33.54 (17.55, 100.85) | 29.40±8.68 (18.63, 40.17) | 38.50±16.16 (21.54, 55.46) | 25.17±13.56 (10.94, 39.39) |
| No. of single-labeled formation events (N.sL.Ev) | 114.00±63.52 (35.13, 192.87) | 49.60±18.74 (26.33, 72.87) | 77.50±29.15 (46.91, 108.09) | 110.33±32.32 (76.42, 144.25) |
| No. of double-labeled formation events per unit bone surface (N.dL.Ev/BS, mm−2) | 3.20±1.32 (1.55, 4.84) | 2.23±0.54 (1.56, 2.90) | 2.25±0.87 (1.34, 3.17) | 1.63±0.98 (0.61, 2.66) |
| No. of single-labeled formation events per unit bone surface (N.sL.Ev/BS, mm−2) | 6.50±3.61 (2.02, 11.00) | 3.76±1.27 (2.19, 5.34) | 4.63±1.89 (2.64, 6.61) | 6.96±1.66 (5.21, 8.71) |
| ††Median 3D mineral apposition rate (3D MAR, µm/day) | 0.71±0.13 (0.54, 0.87) | 0.77±0.11 (0.64, 0.90) | 0.66±0.14 (0.52, 0.81) | 0.47±0.11 (0.35, 0.59) |
| Bone formation rate (BFR/BS, µm/day) | 0.11±0.03 (0.07, 0.15) | 0.13±0.05 (0.07, 0.19) | 0.09±0.04 (0.06, 0.13) | 0.05±0.02 (0.04, 0.07)b |
| ††Median surface area per double-labeled event (MS/dL.Ev, 103 µm2) | 17.26±8.22 (7.06, 27.46)b | 28.53±9.89 (16.25, 40.80) | 18.05±4.53 (13.29, 22.80)b | 14.05±4.77 (9.04, 19.05) abc |
| Median surface area per single-labeled event (MS/sL.Ev, 103 µm2) | 3.31±0.24 (3.01, 3.61) | 3.98±0.41 (3.47, 4.49) | 3.74±0.64 (3.08, 4.41) | 4.34±0.56 (3.76, 4.93) |
| ††Median volume per double-labeled event (V/dL.Ev, 103µm3) | 80.76±41.33 (29.43, 132.08) | 155.71±93.06 (40.16, 271.26) | 91.75±29.20 (61.11, 122.39) | 43.90±21.72 (21.11, 66.69)abc |
††
Median of 7–82 formation events in each specimen
a
p<0.05 vs SHAM group
b
p<0.05 vs OVX group
c
p<0.05 vs OVX+Ral group