Table 4. Adjusted Odds Ratio (OR) for Under-weight Outcomes by TDF Exposure during Pregnancy, among Infants Exposed in Utero to a Combined ARV Regimen.
| TDF Exposure | Birth Weight (n = 2025) | 6-month Weight (n = 1496) | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Gestational age- and sex- adjusted Z-score < 5th percentile |
Gestational age- and sex- adjusted Z-score < 10th percentile |
Age- and sex- adjusted Z-score < 5th percentile |
||||
|
| ||||||
| OR (95% CI) | P-value* | OR (95% CI) | P-value* | OR (95% CI) | P-value* | |
| Any TDF exposure | ||||||
| 0.65 | 1.40 | |||||
| Exposed | 0.89 0.65 (0.52, 1.48) |
1.09 (0.77,1.52) 0.64 |
(0.81,2.36) 0.22 | |||
|
| ||||||
| Trimester of 1st reported exposure |
||||||
| 0.73 | 0.97 | 0.92 | ||||
| 1st trimester | 0.90 (0.49, 1.59) |
1.01 (0.67,1.49) |
1.04 (0.50,1.99) |
|||
| 0.71 | 0.38 | 0.04 | ||||
| 2nd/3rd trimester | 0.85 (0.34, 1.86) |
1.26 (0.74,2.07) |
2.06 (1.01,3.95) |
|||
| Duration of exposure | ||||||
| 0.95 | 0.80 | 0.28 | ||||
| < 4 weeks | 1.06 (0.16, 3.90) |
1.15 (0.33,3.10) |
2.27 (0.36,8.10) |
|||
| 0.99 | 0.53 | 0.51 | ||||
| 4 – 12 weeks | 1.00 (0.33, 2.44) |
0.79 (0.34,1.59) |
1.38 (0.47,3.30) |
|||
| 0.57 | 0.44 | 0.34 | ||||
| > 12 weeks | 0.84 (0.46, 1.48) |
1.16 (0.79,1.66) |
1.34 (0.71,2.40) |
|||
*
P-values from multivariate regression model for adjusted odds ratios. TDF-unexposed was the reference group for all comparisons.
Other covariates included in any of the multivariate regression models: Birth Weight: race, ethnicity, parity, last CD4 count during pregnancy, maternal obesity, gestational diabetes, preeclampsia, smoke during pregnancy; Weight at 6-months of Age: ethnicity