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. Author manuscript; available in PMC: 2013 Nov 6.
Published in final edited form as: Nat Rev Immunol. 2013 Mar 15;13(4):10.1038/nri3407. doi: 10.1038/nri3407

Figure 1. Autoimmune phenomena and adaptive anti-gluten immunity are associated with coeliac disease and are dependent on gluten exposure.

Figure 1

Coeliac disease pathology is characterised by the presence of gluten-specific adaptive immunity and the presence of autoimmune phenomena such as cytotoxic autoantibodies and CD8+ T cells that mediate enterocyte destruction without being gluten specific. Autoimmune and non auto-immune phenomena, as well as tissue pathology, recede when dietary gluten is eliminated and reoccur when gluten is reintroduced.