Table 3.
Events (%) |
Absolute risk difference* |
Hazard ratio (95% CI) |
P value |
||
---|---|---|---|---|---|
Outcomes | Rate-control strategy (n=937) |
Rhythm-control strategy (n=937) |
|||
Cardiovascular mortality | 84 (9%) | 92 (10%) | 1% | 0.88 (0.65–1.18) | 0.39 |
Due to cardiac causes | 65 (7%) | 74 (8%) | 1% | 0.85 (0.61–1.18) | 0.33 |
Arrhythmic | 35 (4%) | 45 (5%) | 1% | 0.75 (0.48–1.16) | 0.20 |
Non-arrhythmic | 30 (3%) | 29 (3%) | 0% | 1.00 (0.60–1.66) | 1.00 |
Due to vascular causes | 19 (2%) | 18 (2%) | 0% | 1.01 (0.53–1.93) | 0.97 |
Non-cardiovascular mortality | 70 (8%) | 108 (12%) | 4% | 0.62 (0.46–0.84) | 0.002 |
All-cause hospitalization | 571 (61%) | 641 (68%) | 7% | 0.76 (0.68–0.86) | <0.001 |
Cardiovascular | 288 (31%) | 387 (41%) | 10% | 0.66 (0.56–0.77) | <0.001 |
Non-cardiovascular | 283 (30%) | 254 (27%) | 3% | 1.07 (0.91–1.27) | 0.42 |
Stroke | 41 (4%) | 44 (5%) | 1% | 0.90 (0.59–1.37) | 0.61 |
Major bleeding** | 78 (8%) | 72 (8%) | 0% | 1.05 (0.77–1.45) | 0.75 |
Absolute risk difference was calculated by subtracting the percentage of events in the rate control group from that in the rhythm control group.
Major bleeding was defined as bleeding requiring transfusion and/or surgery.