. Author manuscript; available in PMC: 2014 Oct 1.

Published in final edited form as: Am J Med. 2013 Oct;126(10):10.1016/j.amjmed.2013.04.021. doi: 10.1016/j.amjmed.2013.04.021

Table 3.

Other outcomes among the subset of AFFRIM patients 70 to 80 years with atrial fibrillation

	Events (%)		Absolute risk difference^*	Hazard ratio (95% CI)	P value
Outcomes	Rate-control strategy (n=937)	Rhythm-control strategy (n=937)	Absolute risk difference^*	Hazard ratio (95% CI)	P value
Cardiovascular mortality	84 (9%)	92 (10%)	1%	0.88 (0.65–1.18)	0.39
Due to cardiac causes	65 (7%)	74 (8%)	1%	0.85 (0.61–1.18)	0.33
Arrhythmic	35 (4%)	45 (5%)	1%	0.75 (0.48–1.16)	0.20
Non-arrhythmic	30 (3%)	29 (3%)	0%	1.00 (0.60–1.66)	1.00
Due to vascular causes	19 (2%)	18 (2%)	0%	1.01 (0.53–1.93)	0.97
Non-cardiovascular mortality	70 (8%)	108 (12%)	4%	0.62 (0.46–0.84)	0.002
All-cause hospitalization	571 (61%)	641 (68%)	7%	0.76 (0.68–0.86)	<0.001
Cardiovascular	288 (31%)	387 (41%)	10%	0.66 (0.56–0.77)	<0.001
Non-cardiovascular	283 (30%)	254 (27%)	3%	1.07 (0.91–1.27)	0.42
Stroke	41 (4%)	44 (5%)	1%	0.90 (0.59–1.37)	0.61
Major bleeding^**	78 (8%)	72 (8%)	0%	1.05 (0.77–1.45)	0.75

Absolute risk difference was calculated by subtracting the percentage of events in the rate control group from that in the rhythm control group.

^**

Major bleeding was defined as bleeding requiring transfusion and/or surgery.