Table 1.
Glomerular function, proximal tubular reabsorption function, proximal tubular structure integrity and distal reabsorption capacity in healthy fullterm infants, healthy preterm infants and diseased preterm infants on days 1 and 3 of postnatal life. Figures are the mean ± SD and analyzed using paired t test for parametric data. From Awad et al. [29].
| Parameters | Healthy fullterm (n = 10) | Healthy preterm (n = 10) | Diseased preterm (n = 30) | |||
|---|---|---|---|---|---|---|
| Day 1 | Day 3 | Day 1 | Day 3 | Day 1 | Day 3 | |
| Glomerular function | ||||||
| Cr Conc. (mg/dL) | 0.79 ± 0.14 | 0.77 ± 0.19 | 0.86 ± 0.21 | 0.84 ± 0.16 | 0.81 ± 0.15 | 0.95 ± 0.18 a |
| Microalbuminuria (µg/mg Cr) | 197 ± 245 | 157 ± 120 | 292 ± 263 | 154 ± 147 | 332 ± 263 | 334 ± 363 |
| Urinary IgG (g/mg Cr) | 0.02 ± 0.05 | 0.003 ± 0.01 | 0.22 ± 0.26 b | 0.05 ± 0.15 a | ||
| Proximal tubular reabsorption function | ||||||
| Urinary α1M (g/mg Cr) | 99.5 ± 84.9 | 64.8 ± 55.3 | 278 ± 235 c | 72.3 ± 56.7 a | 195 ± 117 | 215 ± 171 d |
| Urinary β2M (µg/mg Cr) | 1.56 ± 2.48 | 4.89 ± 7.11 | 3.29 ± 4.69 | 6.12 ± 10.0 | 6.29 ± 4.61 | 8.10 ± 9.88 |
| Urinary RBP (µg/mg Cr) | 1.11 ± 1.69 | 1.22 ± 1.74 | 1.99 ± 2.50 | 1.20 ± 1.02 | 2.71 ± 2.10 | 3.04 ± 2.35 d |
| Proximal tubular structure integrity | ||||||
| Urinary LAP (U/g Cr) | 0.28 ± 0.72 | 0.08 ± 0.06 | 0.47 ± 0.90 | 0.20 ± 0.43 | 0.54 ± 0.75 | 0.21 ± 0.26 |
| Urinary NAG (nmol/min/mg Cr) | 133 ± 192 | 97.7 ± 114 | 407 ± 395 | 108 ± 210 a | 521 ± 582 | 427 ± 474 d |
| Distal reabsorption capacity FeNa% | ||||||
| FeNa% | 1.13 ± 0.98 | 1.48 ± 1.38 | 2.84 ± 3.10 | 1.27 ± 1.45 | 4.01 ± 5.90c | 5.65 ± 6.81 d |
Cr = serum creatinine concentration; IgG = immunoglobulin G; α1M = α1-microglobulin; β2M = β2-microglobulin; RBP = retinol binding protein; LAP = leucine-aminopeptidase; NAG = N-acetyl-β-D-glucosaminidase. ap < 0.05, statistical significant difference between days 1 and 3 within the same group of newborns. bp < 0.05, statistically significant difference between healthy preterm and diseased preterm newborns on day 1. cp < 0.05, statistically significant difference between healthy fullterm and healthy preterm newborns on day 1. dp < 0.05, statistically significant difference between healthy preterm and diseased preterm newborns on day 1.