Table 2.

Results of 3D morphometry of 14 OTSCC cases.

OTSCC cases	Invasion mode(1)	Tissue volume(2)		Border area (S) mm2	S/V p (3)   mm−1	Ki67(+) nucleiin cancer cells(4)		Discohesivecancer foci(5)
		Total mm3	Parenchyma (V p) mm3 (%)			Number	×104/mm3	Number	% volume
A	DS	2.88	0.19 (6.6)	17.2	90.5	20,805	[10.9]	65	(2.83)
B	PB	2.86	0.96 (33.6)	48.3	50.3	221,803	[23.1]	2	(0.0010)
C	PB	2.95	0.56 (21.4)	61.4	97.5	61,896	[9.8]	30	(0.060)
D	PB	2.91	0.37 (12.7)	30.9	83.5	47,913	[12.9]	53	(0.0089)
E	TSC	2.74	0.47 (17.2)	18.3	38.9	23,702	[5.0]	19	(0.44)
F	PB	2.58	0.43 (16.7)	31.3	72.8	108,234	[25.1]	116	(0.26)
G	TSC	2.94	0.20 (6.8)	27.2	136.0	29,009	[14.5]	76	(0.59)
H	PB	2.19	0.92 (42.0)	81.8	88.9	88,303	[9.6]	19	(0.024)
I	TSC	2.91	0.49 (16.8)	24.4	49.8	80,410	[16.4]	7	(0.088)
J	TSC	2.59	0.11 (4.2)	11.2	101.8	18,435	[16.8]	36	(0.33)
K	SF	2.39	0.031 (1.3)	3.8	122.6	4,193	[13.5]	117	(27.1)
L	DS	2.73	0.11 (4.0)	18.4	167.3	35,156	[32.0]	232	(3.76)
M	DS	2.74	0.19 (6.9)	28.8	151.6	45,217	[23.8]	159	(8.34)
N	SF	2.91	0.032 (1.1)	27.2	850.0	9,751	[30.5]	35	(1.69)

⁽¹⁾The abbreviations used are PB, pushing and bulky architecture; TSC, trabecular architecture with strands and cords; DS, diffuse spreading; and SF, special forms.

⁽²⁾The volume data correspond to the reconstructed total tissue volume and the segmented tumor parenchymal volume (V _p). The number in parentheses indicates the volume ratio of V _p to the total tissue.

⁽³⁾ S/V _p indicates the ratio between tumor parenchyma-stroma border area (S) and tumor parenchyma volume (V _p).

⁽⁴⁾The number in brackets indicates the number of Ki67-positive nuclei per tumor parenchyma volume (V _p).

⁽⁵⁾The number in parentheses indicates the volume ratio of discohesive cancer foci to tumor parenchymal volume (V _p).