Table 1.
Formulations of olmesartan liquisolid compacts.
| No. | Drug conc. in vehicle (%w/w)a | R b | Avicel (Q) (mg) | Fujicalin (Q) (mg) | Neusilin (Q) (mg) | Aerosil (q) (mg) | Liquid load factor (L f) | Disintegrantc (mg) | Unit dose (mg) |
|---|---|---|---|---|---|---|---|---|---|
| LSA 1 | 20 | 5 | 285.7 | — | — | 57.4 | 0.28 | 26.57 | 469.6 |
| LSA 2 | 20 | 10 | 370.3 | — | — | 37.0 | 0.27 | 30.43 | 537.4 |
| LSA 3 | 20 | 15 | 416.6 | — | — | 27.7 | 0.24 | 32.65 | 577 |
| LSA 4 | 40 | 5 | 178.5 | — | — | 35.7 | 0.28 | 15.8 | 280 |
| LSA 5 | 40 | 10 | 185.1 | — | — | 18.5 | 0.27 | 15.2 | 268.8 |
| LSA 6 | 40 | 15 | 208.3 | — | — | 13.8 | 0.24 | 16.3 | 288.4 |
| LSA 7 | 20 | 5 | — | 168 | — | 34 | 0.595 | 18.12 | 320.2 |
| LSA 8 | 20 | 10 | — | 194 | — | 19.4 | 0.515 | 18.8 | 332.2 |
| LSA 9 | 20 | 15 | — | 205 | — | 13.6 | 0.488 | 19 | 337.6 |
| LSA 10 | 40 | 5 | — | 84 | — | 16.8 | 0.595 | 9 | 160 |
| LSA 11 | 40 | 10 | — | 97 | — | 9.7 | 0.515 | 9.4 | 166 |
| LSA 12 | 40 | 15 | — | 102 | — | 7 | 0.488 | 9.5 | 168.8 |
| LSA 13 | 20 | 5 | — | — | 100 | 20 | 1.00 | 13.2 | 233.2 |
| LSA 14 | 20 | 10 | — | — | 108 | 10.8 | 0.925 | 13.1 | 232 |
| LSA 15 | 20 | 15 | — | — | 111.3 | 7.4 | 0.898 | 13 | 231.7 |
| LSA 16 | 40 | 5 | — | — | 50 | 10 | 1.00 | 6.6 | 116.6 |
| LSA 17 | 40 | 10 | — | — | 54 | 5.4 | 0.925 | 6.5 | 115.9 |
| LSA 18 | 40 | 15 | — | — | 55.6 | 3.7 | 0.898 | 6.5 | 115.8 |
aAn appropriate amount of liquid medication containing 20 mg drug was incorporated in each tablet.
b R = Carrier : Coating ratio; R = Q/q.
cIncludes 6% (w/w) per tablet of the disintegrant—croscarmellose sodium.