Table 2. Pooled analysis of R- and S-metoprolol pharmacokinetics stratified by CYP2D6 phenotype.
| n | Cmax/dose (ng/mL/mg) | AUC/dose (ug*h/L/mg) | t 1/2 (h) | CL/F (L/h) | |||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| R | S | R | S | R | S | R | S | ||
| UM | 12 | 0.32 [0.24–0.40] |
0.47 [0.33-0.61] |
1.27 [0.86-1.68] |
1.90 [1.34-2.46] |
ND | ND | 547 [393-701] |
380 [272-488] |
| EM | 90 | 0.66 [0.50-0.81] |
0.89 [0.69-1.09] |
2.94 [2.31-3.58] |
4.27 [3.53-5.01] |
3.1 [2.7-3.6] |
3.3 [2.7-3.8] |
170 [131-208] |
104 [91-117] |
| IM | 12 | 1.09 [0.89-1.29] |
1.24 [1.04-1.44] |
7.61 [5.54-9.68] |
9.59 [7.31-11.87] |
4.6 [3.9-5.3] |
5.2 [4.5-5.9] |
61 [46-75] |
48 [36-60] |
| PM | 14 | 1.69 [122-216] |
1.77 [129-225] |
18.39 [16.55-20.24] |
18.03 [16.23-19.84] |
7.8 [7.3-8.3] |
6.8 [6.3-7.3] |
18 [9-27] |
17 [4-31] |
Data presented as mean [95% confidence interval]. UM- ultra-rapid metabolizer, EM- extensive metabolizer, IM- intermediate metabolizer, PM- poor metabolizer, Cmax/dose- peak metoprolol concentration divided by the dose of metoprolol given, AUC/dose- area under the curve divided by the dose of metoprolol given, t½ - half-life, CL/F- oral clearance, ND- not done