Table 2.
Chromosome 22 status by iFISH vs SNP-arrays performed in 15/20 sporadic meningiomas
|
Tumor |
iFISH Karyotype |
Chromosome 22 status by SNP arrays* (n = 6206) |
|||
|---|---|---|---|---|---|
| ID | Chromosome 22 status | Copy number values | N. of SNPs with LOH/N. of informative SNPs (%) | ||
|
M20 |
−22q |
−22 |
1.35 (1.01-1.93) |
108 |
/ 1326 (8%) |
|
M18 |
−22q |
−22 |
1.19 (0.76-1.59) |
365 |
/ 1131 (32%) |
|
M15 |
Complex & -22q |
−22 |
1.30 (0,85-2,03) |
454 |
/ 1158 (39%) |
|
M14 |
−22q |
−22 |
1.34 (0.95-1.77) |
80 |
/ 1472 (5%) |
|
M13 |
−22q |
−22 |
1.24 (0.92-1.8) |
920 |
/ 1188 (77%) |
|
M11 |
Complex & -22q |
−22 |
1.20 (0.91-1.91) |
694 |
/ 1043 (67%) |
|
M16 |
−22q |
−22 |
1.27 (0.81-1.75) |
209 |
/ 1340 (16%) |
|
M7 |
−22q,-Y |
−22 |
1.52 (1.08-2.14) |
18 |
/ 1505 (1%) |
|
M12 |
Complex & del(22q) |
del(22q11.22-qter) |
1.50 (0.98-2) |
19 |
/ 1683 (2%) |
|
M6 |
Complex & del(22q) |
del(22q11.22-qter) |
1.34 (0.8-2.55) |
763 |
/ 1195 (64%) |
|
M19 |
Complex |
Diploid |
1.58 (1.12-2.06) |
7 |
/ 1630 (0.4%) |
|
M10 |
Complex |
Diploid |
1.71 (1.09-2.31) |
9 |
/ 1770 (0.5%) |
|
M9 |
Diploid |
Diploid |
1.75 (1.27-2.32) |
3 |
/ 1712 (0.2%) |
|
M8 |
Diploid |
Diploid |
1.92 (1.6-2.39) |
5 |
/ 1681 (0.3%) |
| M5 | Diploid | Diploid | 1.79 (1.28-2.3) | 3 | / 1696 (0.2%) |
*LOH and copy number analyses involved 6206 SNP localized along the entire chromosome 22.
iFISH interphase fluorescence in situ hybridization, SNP single nucleotide polymorphism, LOH loss of heterozigosity.