Table 2.
Saturated solubility studies of DSL (alone and in presence of poloxamers).
| Composition | Solubility in PBS (mg/mL) | ||||
|---|---|---|---|---|---|
| N1 | N2 | N3 | Mean | SD | |
| DSL | 3.21 | 3.43 | 3.09 | 3.24 | 0.17 |
| DSL + P188 (0.5% w/v) | 3.92 | 4.04 | 4.21 | 4.06 | 0.15 |
| DSL + P188 (2.0% w/v) | 4.11 | 4.26 | 4.3 | 4.22 | 0.10 |
| DSL + P188 (4.0% w/v) | 4.24 | 4.37 | 4.33 | 4.31 | 0.07 |
| DSL + P407 (0.5% w/v) | 3.74 | 3.96 | 3.82 | 3.84 | 0.11 |
| DSL + P407 (2.0% w/v) | 3.89 | 3.95 | 3.91 | 3.92 | 0.03 |
| DSL + P407 (4.0% w/v) | 4.2 | 4.27 | 4.35 | 4.27 | 0.08 |
N1, N2, and N3: replicate measurements; SD: Standard Deviation.