Table 2.
Renal characteristics and outcomes of cohort stratified by renal histopathology
| Crescentic GN n = 18 | Focal GN n = 20 | Mixed n = 27 | Sclerotic n = 11 | p-value | |
|---|---|---|---|---|---|
| Mean number of glomeruli on biopsy (±SD) |
26 ± 11 |
28 ± 16 |
26 ± 11 |
44 ± 32 |
0.018 |
| Mean % normal glomeruli (±SD) |
23 ± 9 |
70 ± 13 |
31 ± 14 |
23 ± 22 |
<0.001 |
| Mean % cellular crescentic glomeruli (±SD) |
63 ± 11 |
13 ± 12 |
24 ± 15 |
14 ± 12 |
<0.001 |
| Mean % globally sclerotic glomeruli (±SD) |
9 ± 8 |
12 ± 12 |
20 ± 15 |
65 ± 10 |
<0.001 |
| Median interstitial fibrosis score (range)* |
1 (0,2) |
1 (0,3) |
2 (0,3) |
2 (2,3) |
<0.001 |
| Median tubular atrophy score (range)* |
1 (0,2) |
1 (0,3) |
2 (0,3) |
2 (2,3) |
<0.001 |
| Mean creatinine (mg/dL) at biopsy (±SD) |
5.2 ± 3.2 |
3.4 ± 4.1 |
3.8 ± 2.3 |
3.2 ± 19 |
0.249 |
| Mean eGFR (mL/min/1.73 m2) at biopsy (±SD) |
16.4 ± 10.3 |
50.2 ± 63.4 |
26.5 ± 23.3 |
26.5 ± 15.0 |
0.035 |
| Mean creatinine (mg/dL) at 6 months (±SD)** |
2.6 ± 3.1 |
1.2 ± 0.4 |
2.1 ± 0.9 |
2.2 ± 0.7 |
0.112 |
| Mean eGFR (mL/min/1.73 m2) at 6 months (±SD)** |
40.8 ± 23.8 |
76.0 ± 38.7 |
42.2 ± 29.6 |
32.8 ± 10.7 |
0.001 |
| Mean creatinine (mg/dL) at 12 months (±SD)§ |
1.9 ± 0.8 |
1.2 ± 0.3 |
2.1 ± 0.8 |
2.4 ± 1.1 |
0.001 |
| Mean eGFR (mL/min/1.73 m2) at 12 months (±SD)§ |
42.1 ± 22.4 |
70.8 ± 29.6 |
37.8 ± 19.8 |
32.7 ± 15.3 |
<0.001 |
| Mean creatinine (mg/dL) at 24 months (±SD)§§ |
1.9 ± 0.8 |
1.1 ± 0.3 |
1.9 ± 0.7 |
2.1 ± 0.8 |
0.007 |
| Mean eGFR (mL/min/1.73 m2) at 24 months (±SD) §§ |
41.7 ± 18.1 |
76.7 ± 29.5 |
42.9 ± 21.6 |
37.8 ± 16.8 |
0.001 |
| Mean change in eGFR (mL/min/1.73 m2) from baseline to 12 mos§ |
25.7 ± 23.4 |
15.9 ± 47.8 |
10.4 ± 14.8 |
1.4 ± 12.3 |
0.373 |
| Hemodialysis required at presentation (%) |
33 |
20 |
37 |
36 |
0.625 |
| Hemodialysis discontinued with treatment of vasculitis (%)Δ |
50 |
75 |
56 |
0 |
0.166 |
| ESRD at 12 months (%) |
22 |
10 |
19 |
27 |
0.549 |
| ESRD at 24 months (%) |
22 |
10 |
22 |
36 |
0.603 |
| Death (%) | 17 | 5 | 11 | 0 | 0.415 |
*Score 0 = none, 1 = mild, 2 = moderate, 3 = severe.
**data calculated from 60 subjects (n = 3 excluded because of missing data; n = 13 excluded because reached ESRD endpoint within 6 months).
§data calculated from 57 subjects (n = 5 excluded because of missing data; n = 14 excluded because reached ESRD endpoint within 12 months).
§§data calculated from 44 subjects (n = 16 excluded because of missing data; n = 16 excluded because reached ESRD endpoint within 24 months).
Δpercentage calculated from number of individuals in class on hemodialysis at presentation.