Table 4.

MMP Relationships with Brain Volumetric Measurements

	Plasma (n=68)					CSF (n=9)
Brain Region	MMP-1	MMP-2	MMP-7	MMP-9	MMP-10	MMP-2	MMP-9
Cerebral Cortex	0.071	0.230†	−0.086	−0.005	−0.200	−0.517	0.117
Cerebral WM	−0.259*	−0.084	0.010	0.107	−0.265*	0.083	−0.317
Cerebellum Cortex	0.059	0.025	−0.247*	0.096	−0.036	0.017	0.150
Cerebellum WM	−0.135	0.137	0.017	−0.103	−0.105	0.200	−0.267
Corpus Callosum	−0.232	0.034	0.030	0.092	0.120	−0.401	−0.413
Caudate	−0.170	−0.198	−0.085	−0.065	−0.217†	−0.700*	0.067
Putamen	0.076	−0.148	0.009	0.007	−0.137	−0.717*	0.100
Pallidum	0.004	−0.043	0.014	−0.068	0.026	− 0.883 **	−0.133
Accumbens	0.052	−0.101	−0.147	0.060	−0.166	−0.750*	−0.150
Amygdala	0.066	−0.003	−0.262*	0.095	−0.222†	0.017	0.133
Hippocampus	0.042	0.073	−0.041	0.123	−0.011	−0.433	−0.317
Ventral Diencephalon	−0.233†	0.028	0.073	−0.106	0.060	−0.233	−0.050
Thalamus	−0.061	0.014	0.064	−0.182	−0.082	−0.483	−0.317
Brain Stem	−0.296*	0.072	0.080	−0.084	0.037	0.000	−0.400
Third Ventricle	−0.091	−0.148	0.058	0.080	−0.090	0.267	−0.317
Fourth Ventricle	−0.345*	−0.146	−0.007	−0.260*	−0.258*	−0.233	0.450
Inf Lateral Ventricles	−0.149	0.054	0.134	0.055	0.015	−0.200	−0.667*
Lateral Ventricles	0.030	−0.093	0.079	0.168	−0.130	0.050	−0.117

Pearson correlation coefficients (Spearman used for MMP-9 and CSF).

Lateralized regions have been summed for left and right hemisphere; WM: White matter

Bold correlation coefficient: Significant at the Bonferroni corrected level of 0.05/18.

^**Significant at the 0.01 level.

^*Significant at the 0.05 level.

^†Significant at the 0.10 level.