Table 5.

MMP Relationships with Autoregional DTI Brain Measurements

	Plasma (n=69)					CSF (n=9)
Fractional Anisotropy (FA)	MMP-1	MMP-2	MMP-7	MMP-9	MMP-10	MMP-2	MMP-9
Whole Brain	−0.140	0.053	0.220†	−0.040	−0.103	−0.441	−0.380
Whole Brain WM	−0.207†	0.356 **	0.146	−0.112	−0.004	−0.561	−0.337
Cerebral Cortex	0.031	−0.148	0.018	−0.035	−0.068	0.417	0.234
Cerebral WM	−0.309**	0.298*	0.073	−0.165	0.007	−0.714*	−0.274
Corpus Callosum	−0.254*	0.053	0.033	0.004	−0.026	−0.739*	−0.445
Caudate	−0.086	0.019	0.250*	−0.144	0.069	0.629	0.502
Putamen	0.139	−0.061	0.140	−0.030	−0.051	0.512	0.037
Hippocampus	0.239*	−0.155	0.057	−0.146	0.152	−0.438	−0.143
Thalamus	−0.059	0.165	0.177	−0.003	−0.086	−0.389	−0.328
Mean Diffusivity (MD)	MMP-1	MMP-2	MMP-7	MMP-9	MMP-10	MMP-2	MMP-9
Whole Brain	−0.153	− 0.398 **	−0.307*	0.077	−0.030	−0.251	−0.617†
Whole Brain WM	0.002	− 0.340 **	−0.088	0.171	−0.094	0.234	−0.136
Cerebral Cortex	0.073	− 0.392 **	−0.209†	0.145	−0.157	0.505	−0.143
Cerebral WM	0.061	− 0.363 **	−0.087	0.187	−0.119	0.459	−0.146
Corpus Callosum	−0.017	0.086	0.199	−0.097	−0.018	−0.133	−0.339
Caudate	−0.042	0.142	0.301*	−0.036	0.137	−0.237	−0.736*
Putamen	−0.065	−0.299*	−0.279*	0.172	−0.053	−0.007	0.189
Hippocampus	−0.222†	0.016	−0.208†	0.015	−0.250*	0.227	0.108
Thalamus	−0.090	−0.274*	−0.220†	0.059	−0.095	−0.110	0.502

Pearson correlation coefficients (Spearman used for MMP-9 and CSF).

Lateralized regions have been averaged for left and right hemisphere; WM: White matter

Bold correlation coefficient: Significant at the Bonferroni corrected level of 0.05/9.

^**Significant at the 0.01 level.

^*Significant at the 0.05 level.

^†Nearly significant (p < 0.10).