Figure 1.

Genomic organization and amino acid sequence. (A) The zebrafish podocalyxin and human PODOCALYXIN genes contained eight and nine protein-coding exons, respectively. Red rectangles indicate the sites targeted by the morpholinos used. (B) ClustalW alignment of amino acid sequences. In both animals, the orthologues contain a bulky mucin domain (dark blue), a disulfide-bonded globular domain (bluegreen), a transmembrane region (green), and a cytoplasmic tail (pink), in this order. Cysteine residues in the globular domain are indicated by framed rectangles.