Figure 2.
PICRUSt recapitulates biological findings from the Human Microbiome Project. A) PCA plot comparing KEGG Module predictions using 16S data with PICRUSt (lighter colored triangles) and sequenced shotgun metagenome (darker colored circles) along with relative abundances for five specific KEGG Modules, B) M00061: Uronic acid metabolism, C) M00076: Dermatan sulfate degradation, D) M00077: Chondroitin sulfate degradation, E) M00078: Heparan sulfate degradation, and F) M00079: Keratan sulfate degradation, all involved in glycosaminosglycan degradation (KEGG pathway ko00531) using 16S with PICRUSt (P, lighter colored) and WGS (W, darker colored) across human body sites: nasal (blue), gastrointestinal tract (brown), oral (green), skin (red), and vaginal (yellow).