Figure 7. RTEs contribute to the peripheral CD8 T cell response during chronic infection.

Infected mice were administered 0.6 mg of busulfan on the indicated days post-infection. One day later, 1.5×10⁷ T cell- depleted bone marrow cells from C57BL/6 mice were injected, and Tb10.4_4-11/K^b antigen-specific CD8 T cells were quantitated in the lungs. (A) Analyses of donor and host T cells are shown. The numbers in the dot plots indicate the frequencies of Tb10.4_4-11/K^b antigen-specific CD8 T cells after donor-bone marrow transfer in mice treated with busulfan on day 30, day 90 post-infection. (B) The number of Tb10.4_4-11/K^b -specific host and donor CD8 T cells after donor-bone marrow reconstitution is shown.