Table 2.
Study | Country | Study design |
Study dates |
Patient population1 |
Trial agents | Method of SIBO diagnosis |
Test of SIBO eradication |
Days of antibiotic restriction before testing |
Dietary restrictions2 | Other restrictions |
---|---|---|---|---|---|---|---|---|---|---|
Collins 2011 | United States | DB, RCT | Not reported | Children with chronic abdominal pain | Rifaximin versus placebo | LBT | LBT normal 14 days after treatment | 60 | Light meal the night before | No probiotics for 60 days |
Chang 2011 | United States | DB, RCT | 2006–2008 | Celiac patients with abdominal symptoms | Rifaximin versus placebo | LBT | LBT normal 4 days after treatment | 30 | Multiple food exclusions the day before | None |
Furnari 2010 | Italy | OL, RT | 2007–2010 | Adults with SIBO symptoms | Rifaximin versus Rifaximin plus PHGG | GBT | GBT normal 30 days after treatment | 10 | Boiled rice, meat and water the night before | No probiotics or proton pump inhibitors for 10 days |
Lauritano 2009 | Italy | OL, RT | 2005–2007 | Adults with SIBO symptoms | Rifaximin versus metronidazole | GBT | GBT normal 30 days after treatment | 90 | Carbohydrate restricted the night before | No laxatives for 30 days |
Scarpellini 2007 | Italy | OL, RT | 2004–2006 | Adults with SIBO symptoms | Rifaximin (compared multiple doses) | GBT | GBT normal 30 days after treatment | 90 | Carbohydrate restricted the night before | No laxatives for 30 days |
Lauritano 2005 | Italy | OL, RT | 2003–2004 | Adults with SIBO symptoms | Rifaximin (compared multiple doses) | GBT | GBT normal 30 days after treatment | 30 | Carbohydrate restricted the night before | No laxatives for 30 days |
Castiglione 2003 | Italy | OL, RT | 2000–2002 | Adults with Crohn’s disease | Metronidazole versus ciprofloxacin | LBT followed by GBT | GBT normal 7 days after treatment | 30 | No starch for 48 hours | None |
Pimentel 2003 | United States | DB, RCT | Not reported | Adults meeting Rome I criteria for IBS | Neomycin versus placebo | LBT | LBT normal 7 days after treatment | 90 | No legumes or heavy foods the night before | “All use prohibited” |
Biancone 2000 | Italy | Blinded3, RT | Not reported | Adults with Crohn’s disease | Rifaximin versus placebo | GBT | GBT normal 14 days after treatment | Not reported | No specific restrictions | None |
DiStefano 2000 | Italy | DB, RT | Not reported | Adults with SIBO symptoms | Rifaximin versus chlortetracycline | GBT | GBT normal 3 days after treatment | 30 | Rice, meat and olive oil the evening before | None |
DB, double-blinded; GBT, glucose breath test; IBS, irritable bowel syndrome; LBT, lactulose breath test; OL, open-label; PHGG, partially hydrolyzed guar gum; RCT, randomized controlled trial; RT, randomized trial; SIBO, small intestinal bacterial overgrowth
These data are meant to be descriptive and do not represent analytical subgroups
Unless otherwise stated, subjects were NPO for 12 hours before testing
Unclear whether single- or double-blinded