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. Author manuscript; available in PMC: 2014 Sep 11.
Published in final edited form as: Cell Host Microbe. 2013 Sep 11;14(3):10.1016/j.chom.2013.08.012. doi: 10.1016/j.chom.2013.08.012

Figure 2. Multiple late assembly domains of HIV-1 Gag recruit different ESCRT-associated factors that may work together to facilitate virus budding.

Figure 2

The model suggests how three different early-acting ESCRT-associated factors recruited by HIV-1 Gag -- NEDD4L (pink), ESCRT-I (red) and dimeric ALIX (dark blue) -- could work together in a stepwise fashion to facilitate virus budding. The three regions of HIV-1 Gag are depicted in yellow (MA), orange (CA) and red (NC, bound to blue RNA), the subunits of the trimeric viral Env protein are depicted in blue (SU/gp120) and pink (TM/gp41), and ESCRT-III proteins (light green) are depicted schematically as either polymeric filaments (central panel, light green ring) or soluble, autoinhibited subunits (right panel, discrete subunits). ESCRT-I is missing from the final panel because the ultimate fate of this complex is not yet clear.