Fig. 2.

CCR5 ligand binding pocket for Maraviroc. (A) Key residues in CCR5 for Maraviroc binding. Maraviroc (orange carbons) and receptor residues (blue carbons) involved in ligand binding are shown in stick representation. Other elements are colored as follows: oxygen, red; nitrogen, dark blue; sulfur, yellow; fluorine, light-cyan. The water molecule involved in interacting with Maraviroc is shown as a red sphere. (B) Schematic representation of interactions between CCR5 and Maraviroc. Mutations reported to be critical for Maraviroc binding are indicated with blue squares (11, 16).