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. Author manuscript; available in PMC: 2014 Feb 25.
Published in final edited form as: Angew Chem Int Ed Engl. 2013 Jan 21;52(9):10.1002/anie.201208957. doi: 10.1002/anie.201208957

Table 3.

Catalytic enantioselective intermolecular γ-addition of 2,2,2-trifluoroacetamide to allenoates: Scope.

graphic file with name nihms521614t9.jpg
entry R ee (%) yield (%)[a]
1 Me 86 89
2 n Pr 87 90
3 iBu 88 92
4 (CH2)2Ph 88 94
5 (CH2)4OBn 89 87
6 graphic file with name nihms521614t10.jpg 89 86
7 graphic file with name nihms521614t11.jpg 87 88
8 (CH2)2CO2Me 82 68
9 graphic file with name nihms521614t12.jpg 86 87

All data are the average of two experiments.

[a]

Yield of purified product (E:Z >95:5).