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. 2013 Nov 6;8(11):e79817. doi: 10.1371/journal.pone.0079817

Figure 1. Mefloquine treatment causes degeneration of cochlear hair cells and auditory nerves, while NAD+ reduces the degeneration.

Figure 1

Hair cells (green fluorescence) and auditory nerve fibers (red fluorescence) in the apical turn and the basal turn of the cultured cochlea without mefloquine treatment (untreated) (a-d), or treated with 35 µM mefloquine alone (e-f), 50 µM mefloquine alone (g-h), 35 µM mefloquine + 5 mM NAD+ (i-j), 50 µM mefloquine + 5 mM NAD+ (k-l), 35 µM mefloquine + 20 mM NAD+ (m-n) or 50 µM mefloquine + 20 mM NAD+ (o-p).