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. 2013 Nov 6;8(11):e79817. doi: 10.1371/journal.pone.0079817

Figure 7. Mefloquine increases active caspase-3-positive spiral ganglion neurons, while NAD+ prevents the increases.

Figure 7

Red fluorescence indicates active caspases-3 in the spiral ganglion neurons in cultured cochlea without mefloquine treatment (a), or treated with 35 µM mefloquine alone (b) or 35 µM mefloquine + 20 mM NAD+ (c). Active caspase-3-positive cells were quantified in the spiral ganglion neuron regions (d). *Significantly different from control (P < 0.05). **Significantly different from mefloquine treatment alone (P < 0.05). 35 Mef = 35 µM mefloquine, and 20 NAD+ = 20 mM NAD+. Arrows indicate caspases-3-positive cells.