Table 1. Proteins more highly expressed in DLBCL cell lines (HT and SU) than in the B-LCL determined using comparative proteomic analysis.
Uniprot Acc# | Protein Name | Location |
Signal intensity (average)
|
Ratio
|
|||
---|---|---|---|---|---|---|---|
HT | SU | LCL | HT/LCL | SU/LCL | |||
P23526 | Adenosylhomocysteinase | Cytoplasm | 4484400 | 4518400 | 3144300 | 1.43 | 1.44 |
P27707 | Deoxycytidine kinase | Nucleus | 638620 | 497930 | 79610 | 8.02 | 6.25 |
P52701 | DNA mismatch repair protein Msh6 | Nucleus | 0 | 5932900 | 807720 | 0 | 7.35 |
P49736 | DNA replication licensing factor MCM2 | Nucleus | 6241500 | 10184000 | 4821100 | 1.29 | 2.11 |
P25205 | DNA replication licensing factor MCM3 | Nucleus | 5105500 | 5689800 | 3205400 | 1.59 | 1.78 |
P33991 | DNA replication licensing factor MCM4 | Nucleus | 8135000 | 14964000 | 5048900 | 1.61 | 2.96 |
P33992 | DNA replication licensing factor MCM5 | Nucleus | 4448300 | 9623600 | 2634800 | 1.69 | 3.65 |
Q14566 | DNA replication licensing factor MCM6 | Nucleus | 8205700 | 9524200 | 3819200 | 2.15 | 2.49 |
P33993 | DNA replication licensing factor MCM7 | Nucleus | 7250500 | 15046000 | 5793800 | 1.25 | 2.6 |
C9J4C3 | DNA topoisomerase 2 | Nucleus | 5475900 | 13128000 | 1458800 | 3.75 | 9 |
Q02880 | DNA topoisomerase 2-beta | Nucleus | 2538400 | 952320 | 626520 | 4.05 | 1.52 |
P62807 | Histone H2B type 1-C/E/F/G/I | Nucleus | 85579000 | 162440000 | 129050000 | 0.66 | 1.26 |
P36776 | Lon protease homolog, mitochondrial | Mitochondria | 2233600 | 7393900 | 2772700 | 0.81 | 2.67 |
Q14676 | Mediator of DNA damage checkpoint protein 1 | Nucleus | 6142000 | 1894700 | 1541300 | 3.98 | 1.23 |
P19338 | Nucleolin, isoform 1 | Nucleus | 102890000 | 90123000 | 58881000 | 1.75 | 1.53 |
P13010 | Protein X-ray repair cross-complementing protein 5 | Nucleus | 22411000 | 22996000 | 19606000 | 1.14 | 1.17 |
P46060 | Ran GTPase-activating protein 1 | Cytoplasm & nucleus | 1220100 | 1154900 | 911260 | 1.34 | 1.27 |
P43487 | Ran-specific GTPase-activating protein | Nucleus | 5070100 | 2663300 | 3566000 | 1.42 | 0.75 |
P23246 | Splicing factor, proline- and glutamine-rich | Nucleus | 41996000 | 35759000 | 22272000 | 1.89 | 1.61 |
Q13428 | Treacle protein, isoform 2 | Nucleus | 9425700 | 14198000 | 6420200 | 1.47 | 2.21 |
Abbreviations: DLBCL, diffuse large B-cell lymphoma; B-LCL, B-lymphoblastoid cell line.