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. 2013 Nov 6;8(11):e79863. doi: 10.1371/journal.pone.0079863

Table 1. Proteins more highly expressed in DLBCL cell lines (HT and SU) than in the B-LCL determined using comparative proteomic analysis.

Uniprot Acc# Protein Name Location Signal intensity (average)
Ratio
HT SU LCL HT/LCL SU/LCL
P23526 Adenosylhomocysteinase Cytoplasm 4484400 4518400 3144300 1.43 1.44
P27707 Deoxycytidine kinase Nucleus 638620 497930 79610 8.02 6.25
P52701 DNA mismatch repair protein Msh6 Nucleus 0 5932900 807720 0 7.35
P49736 DNA replication licensing factor MCM2 Nucleus 6241500 10184000 4821100 1.29 2.11
P25205 DNA replication licensing factor MCM3 Nucleus 5105500 5689800 3205400 1.59 1.78
P33991 DNA replication licensing factor MCM4 Nucleus 8135000 14964000 5048900 1.61 2.96
P33992 DNA replication licensing factor MCM5 Nucleus 4448300 9623600 2634800 1.69 3.65
Q14566 DNA replication licensing factor MCM6 Nucleus 8205700 9524200 3819200 2.15 2.49
P33993 DNA replication licensing factor MCM7 Nucleus 7250500 15046000 5793800 1.25 2.6
C9J4C3 DNA topoisomerase 2 Nucleus 5475900 13128000 1458800 3.75 9
Q02880 DNA topoisomerase 2-beta Nucleus 2538400 952320 626520 4.05 1.52
P62807 Histone H2B type 1-C/E/F/G/I Nucleus 85579000 162440000 129050000 0.66 1.26
P36776 Lon protease homolog, mitochondrial Mitochondria 2233600 7393900 2772700 0.81 2.67
Q14676 Mediator of DNA damage checkpoint protein 1 Nucleus 6142000 1894700 1541300 3.98 1.23
P19338 Nucleolin, isoform 1 Nucleus 102890000 90123000 58881000 1.75 1.53
P13010 Protein X-ray repair cross-complementing protein 5 Nucleus 22411000 22996000 19606000 1.14 1.17
P46060 Ran GTPase-activating protein 1 Cytoplasm & nucleus 1220100 1154900 911260 1.34 1.27
P43487 Ran-specific GTPase-activating protein Nucleus 5070100 2663300 3566000 1.42 0.75
P23246 Splicing factor, proline- and glutamine-rich Nucleus 41996000 35759000 22272000 1.89 1.61
Q13428 Treacle protein, isoform 2 Nucleus 9425700 14198000 6420200 1.47 2.21

Abbreviations: DLBCL, diffuse large B-cell lymphoma; B-LCL, B-lymphoblastoid cell line.