Table 1. Parameters of high-fat diet-induced obese mice.
HFD + Mifepristone (mg/kg BW/day) | 0 | 0.1 | 1 | 30 |
---|---|---|---|---|
Total body weight [g] | 45.2 ± 1.1 | 43.8 ± 1.4 | 44.6 ± 1.1 | 44.0 ± 1.4 |
Food consumption [g/day] | 3.04 ± 0.04 | 2.96 ± 0.06 | 3.04 ± 0.05 | 3.04 ± 0.04 |
Fasting blood glucose [mg/dL] | 234.3 ± 9.4 | 190.2 ± 8.7 * | 177.7 ± 13.9 ** | 179.8 ± 14.6 ** |
Seven-week-old C57BL/6NCr Slc mice received a high-fat diet (HFD) and were orally treated with either mifepristone (0.1, 1 or 30 mg/kg bw/day) or vehicle (HFD alone) for 22 consecutive weeks (n = 8 in each group). At the 28 weeks of age, animals were subjected to a fasting blood glucose test. * p < 0.05, ** p < 0.01 versus HFD fed mice that did not receive mifepristone.