Table 3. Evolution of parameters during osmotic challenge.
| Overall N=30 | Responders N=12 | Non-Responders N= 18 | p | ||
|---|---|---|---|---|---|
| Plasma sodium level (mmol/l) | |||||
| Onset of test | 136 (135-138) | 137 (135-138) | 136 (134-139) | 0.97 | |
| End of test | 146 (143-149) | 147 (145-148) | 145 (143-149) | ||
| Variation of plasma Na | 10 (8-12) | 10 (9-12) | 9 (8-12) | 0.67* | |
| Brain natriuretic peptide (ng/ml) | |||||
| Onset of test | 380 (178-618) | 594 (181-719) | 314 (179-553) | 0.58 | |
| End of test | 336 (170-630) | 450 (186-558) | 328 (179-514) | 0.41 | |
| Body temperature (°C) | |||||
| Onset of test | 37.1 (36.7-37.5) | 37.0 (36.6-37.4) | 37.2 (36.8-37.6) | ||
| Plasma creatinine level (µmol/l) | |||||
| Onset of test | 69 (51-111) | 87 (62-113) | 58 (48-103) | ||
| Plasma Cortisol level (µmol/l) | |||||
| Onset of test | 155 (144-207) | 152 (143-162) | 161 (146-217) | ||
| PCT (ng/ml) | |||||
| Onset of test | 0.3 (0.1-1.3) | 0.3 (0.2-1.9) | 0.3 (0.1-0.6) | ||
| Plasma AVP level (pg/ml) | |||||
| Onset of test | 2.6 (2.2-3.6) | 3.2 (2.3-4.6) | 2.5 (2.2-2.9) | 0.31 | |
| End of test | 7.1(4.5- 13.9) | 16.4(10.6-24.6) | 4.7 (3.9-6.7) | ||
| Variation of plasma ADH | 3.7 (2.0-9.2) | 10.1 (7.4-20.1) | 2.1 (1.3-3.0) | <0.0001* | |
| Thirst VAS level (cm) | |||||
| Patients evaluated (%) | 21 (70.0) | 7 (58.3) | 14 (77.8) | ||
| Onset of test | 2.0 (1.0-3.0) | 2.0 (0.5-2.5) | 2.0 (1.0-2.8) | 0.76 | |
| End of test | 6.0 (5.0-8.0) | 8.0 (6.5-9.5) | 5.5 (3.3-6.0) | ||
| Variation of thirst | 4 (1.8-6) | 6 (5.5-7.5) | 3 (1.3-4) | 0.014 | |
Data are median (IQR) for continuous variables and n (%) for categorical variables
* test for equal variation in the mixed models analysis of covariance