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. Author manuscript; available in PMC: 2013 Nov 6.
Published in final edited form as: Dev Biol. 2009 Sep 22;336(1):42–52. doi: 10.1016/j.ydbio.2009.09.023

Fig. 7. Models for long-range regulation of Tel7KI.

Fig. 7

(A) The maternal chromosome is marked by a DNA methylation imprint at IC2. The Tel7KI promoter is unmethylated and active. (B) In the first model, the germline imprint on the paternal IC1 spreads not only to Igf2 but also to Tel7KI. Whereas this inhibits the function of Igf2 silencers, the promoter methylation leads to silencing of the paternal Tel7KI allele. (C) Another model implicates long-range silencing on the paternal chromosome by formation of the Kcnq1ot1 non-coding RNA, which bidirectionally spreads repressive histone marks in the IC2 cluster (dotted lines) and silencing DNA methylation at Cdkn1c and Tel7KI (solid lines).