Figure 6. Selected N-terminal peptide derivatives synthesized from the second-phase diversification and quantification of their inhibitory activities against Plk1 PBD.

(A) Second-phase N-terminal-truncated PLHSpTM peptide derivatives generated using solid-phase peptide synthesis (SPPS) to study the binding nature of the pyrrolidine-binding region. (B) ELISA-based Plk1 PBD-binding IC₅₀ graph (O.D., optical density). A representative graph from three independent experiments.