Table 2. BGN mRNA expression levels are elevated in muscle invasive tumors, high-grade tumors, non-smoking and female gender patients.
| BGN gene expression | P | ||
|---|---|---|---|
| values | |||
| Σ = 76 | median (range) | ||
| Age | |||
| ≤ 65 | 35 | 2.81 (0.06-24.33) | 0.847 |
| > 65 | n | 1.95 (0.06-8.28) | |
| Gender | |||
| Male | 59 | 1.66 (0.06-8.28) | 0.003 |
| Female | 17 | 4.86 (0.16-24.33) | |
| Stage | |||
| Ta | 19 | 1.00 (0.13-4.01) | 0.986 |
| T1 | 15 | 1.06 (0.12-4.26) | 0.512 |
| T2 | 14 | 1.30 (0.06-5.53) | 0.069 |
| T3 | 14 | 3.78 (0.23-12.62) | 0.909 |
| T4 | 14 | 5.21 (0.24-24.33) | |
| Non-invasive | 34 | 1.03 (0.12-4.26) | 0.004 |
| Muscle-invasive | 42 | 3.37 (0.06-24.33) | |
| Grade | |||
| G1 | 13 | 0.76 (0.12-4.01) | 0.919 |
| G2 | 27 | 1.08 (0.13-4.26) | 0.002 |
| G3 | 36 | 3.80 (0.06-24.33) | |
| Low-grade (G 1-2) | 38 | 0.97 (0.12-4.26) | 0.001 |
| High-grade (G 3) | 37 | 3.76 (0.06-24.33) | |
| Lymph node | |||
| N0/Nx | 62 | 2.05 (0.06-24.33) | 0.196 |
| N + | 14 | 3.66 (0.23-15.3) | |
| Primer | 43 | 3.01 (0.12-24.33) | 0.883 |
| Recurrent | 33 | 1.44 (0.06-8.08) | |
| Smoking | |||
| yes | 42 | 2.01 (0.06-24.33) | 0.008 |
| no | 23 | 3.40 (0.13-15.28) | |
| unknown | 18 |
mRNA gene expression levels of n=76 patients with bladder cancer. Data were obtained from flash-frozen tumor samples. Univariate Cox proportional hazard survival regression analysis was used for data analysis, a p-value <0.05 was considered as significant.