Table 3. Dosing intervals by dose number and timing status.

	Doublet	Triplet	Quadruplet
	N = 818	N = 1464	N = 60
On-Time†	745 (91%)	1005 (69%)	21 (35%)
Early Dosing
Dose 2 from Dose 1	0 (0%)	2 (<1%)	2 (3%)
Dose 3 from Dose 2		27 (2%)	2 (3%)
Dose 3 from Dose 1‡		56 (4%)	4 (7%)
Late Dosing
Dose 2 from Dose 1	73 (9%)	46 (3%)	1 (2%)
Dose 3 from Dose 1		83 (6%)	3 (5%)
Two Dosing Intervals Inappropriately Timed		20 (1%)	2 (3%)
Extra doses after a mistimed three dose series			32 (53%)
Extra doses after an appropriately timed three dose series*			7 (12%)

†Significant difference among doublet, triplet and quadruplet on-time doses, p<0.001.

‡Early interval of dose 3 from dose 1 occurred significantly more often than other early dosing intervals, p<0.002.

^*Six of the seven extra doses were prior to the appropriately timed triplet, and one of the seven was after the appropriately timed triplet.