Table 3. Prevalence of the CNTNAP4 CNVR6782.1del/del variant in ≥80 years old seniors (PolSenior collection) with cognitive impairment, and with other pathologies in the absence of cognitive impairment.

Disease	Sex	n	Prevalence (%)
			Control*	Case**	OR	95%CI	Fisher p
Cognitive impairment	M+F	341	39	49	1.53	0.98-2.38	0.060
	F	172	30	48	2.17	1.11-4.22	0.024
	M	169	46	51	1.20	0.65-2.20	0.642
Other pathologies	M+F	316	39	41	1.08	0.68-1.70	0.817
	F	140	30	34	1.19	0.57-2.44	0.716
	M	176	46	38	1.01	0.55-1.83	1.0

M: males; F: females.

The mean age was 83.5±3.63 years (n=60) in healthy females, 85.2±3.84 years in females with cognitive impairment (n=112), and 83.1±4.36 in females with other pathologies (n=80). In males, it was 84.9±3.57 years (n=74), 85.5±3.30 (n=95) and 84.0±3.23 (n=102), respectively.

^*Subjects with MMSE score ≥24 and no chronic diseases in medical records.

^**In “Cognitive impairment” subgroup, these are subjects with MMSE score <24 and other pathologic conditions might or might not be present. In “Other pathologies” subgroup, these are subjects with MMSE score ≥24, but with one or more of chronic diseases present.