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. 2013 Nov 6;8(11):e76161. doi: 10.1371/journal.pone.0076161

Figure 3. Patterns of glucose and insulin secretion in the 75gOGTT in relation to the progression of hepatic fibrosis.

Figure 3

A) The glucose levels were significantly elevated in accordance with the progression of fibrosis (Versus F0: *P<0.05, **P<0.01; Versus F1: # P<0.05, ### P<0.001; Versus F2: + P<0.05). B) Area under the curve (AUC) of plasma glucose levels (AUC-PG) was remarkably larger in accordance with the progression of hepatic fibrosis (F0 versus F2, *P<0.05; F0 versus F3, **P<0.01; F1 versus F3, # P<0.05; F2 versus F3, + P<0.05) C) Insulin secretion levels were remarkably higher in the patients with progression of hepatic fibrosis (Versus F0: *P<0.05, **P<0.01; Versus F1: # P<0.05, ## P<0.01, ### P<0.001). D) AUC of insulin secretion (AUC-IRI) was also significantly larger in accordance with the progression of hepatic fibrosis (F0 versus F3, *P<0.05; F1 versus F3, ## P<0.01). (Black diamond: F0: n = 10. Gray square: F1: n = 74. Black triangle: F2: n = 48. Gray circle: F3: n = 37; total, N = 169).