Table 2. Clinical validity and responsiveness of the 17-item Hamilton depression rating scale (HAM-D17) and the 6-item melancholia subscale (HAM-D6).
| Clinical validity | |||
| Week 4 (n=185) | Week 8 (n=144) | Week 12 (n=135) | |
| HAM-D17 | 0.76 | 0.80 | 0.82 |
| HAM-D6 | 0.74 | 0.78 | 0.82 |
| Responsiveness | |||
| Week 4 (LOCF) | Week 8 (LOCF) | Week 12 (LOCF) | |
| HAM-D17 | -0.80 | -0.79 | -0.81 |
| HAM-D6 | -0.77 | -0.80 | -0.83 |
Above - clinical validity: Spearman correlation analysis for the total scores on the HAM-D17 and the HAM-D6 versus Clinical Global Impression – Severity (CGI-S) scores at week 4, 8 and 12. Below - responsiveness: Spearman correlation analysis for the change in total scores from baseline to week 4, 8 and 12 on the HAM-D17 and the HAM-D6 versus Clinical Global Impression – Improvement (CGI-I) scores at week 4, 8 and 12 (n=252 - Last observation carried forward (LOCF)). All correlations were statistically significant (p<0.001).