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. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: J Med Chem. 2013 Jun 25;56(13):10.1021/jm400575x. doi: 10.1021/jm400575x

Scheme 5.

Scheme 5

Synthesis of (E)-N-Aryl-2-arylethenesulfonamides (6) from Phenacyl N-Arylsulfonesa

a Reagents and conditions: (a) SOCl2, DCM, room temp, 6 h, 81% or (COCl)2, DMF, anhydrous CH2Cl2, room temp, 12 h, 67%; (b) AlCl3, DCM, room temp, 4 h, 80%; (c) NaBH4, THF, room temp, 3 h, 88%; (d) p-TSA, toluene, reflux, 3 h, 78%.