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Plasma 6t concentrations (mean ± SD) following either administration of 5 mg/kg as an IV bolus or oral gavage to normal mice. The resultant IV PK parameters were; total clearance = 2.48 ± 0.19 L/h/kg, volume of distribution at steady-state = 2.13 ± 0.46 L/kg and an elimination half-life of 1.7 h. Oral bioavailability equaled 34% based on ratio of the AUCpo = 0.70 ± 0.42 μg-h/mL to the AUCiv = 2.04 ± 0.17 μg-h/mL.
