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. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: J Med Chem. 2013 Jun 25;56(13):10.1021/jm400575x. doi: 10.1021/jm400575x

Scheme 1.

Scheme 1

Synthesis of (E)-N-Aryl-2-arylethenesulfonamides (6) from N-Arylsulfonylacetic Acidsa

a Reagents and conditions: (a) Et3N, DCM, room temp, 3 h, 80%; (b) 10% NaOH, H2O, room temp, 3 h, 84%; (c) C6H5CH2NH2, AcOH, reflux, 8 h, 50%; (d) piperidine, benzoic acid, toluene, reflux, 4 h, 60%.