. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Aging Cell. 2013 Jul 29;12(6):10.1111/acel.12127. doi: 10.1111/acel.12127

Table 1.

Bioenergetic Parameters of Primary Cortical Neurons Effect of Lipoic Acid

	OCR (pmoles/min)
	Control	LA	LY294002	LA + LY294002
Basal respiration	344 ± 27	439 ± 55^*	225 ± 18	285 ± 17^ψ
OXPHOS-induced respiration	190 ± 29	254 ± 63^*	124 ± 20	149 ± 21^ψ
H+ leak-induced respiration	154 ± 11	184 ± 31^*	100 ± 8	136 ± 12^ψ
Maximal respiratory capacity	691 ± 63	950 ± 114^*	396 ± 45	467 ± 36^ψ
Non-mitochondrial respiration	114 ± 10	142 ± 27^*	55 ± 7	66 ± 12^ψ
Reserve capacity	347 ± 69	512 ± 127^*	171 ± 49	182 ± 40^ψ

Assay conditions as described in the Methods section.

p < 0.05 versus control.

^ψ

p > 0.05 versus lipoid acid treatment group.