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. Author manuscript; available in PMC: 2013 Nov 6.
Published in final edited form as: Transl Cancer Res. 2013 Jun;2(3):1219.

Table 1.

Involvement of human DNA ligases in DNA replication and repair pathways

Nuclear DNA metabolism
  DNA republication DNA ligase I
DNA ligase III (backup)
  Mismatch repair Unknown
  Base excision repair DNA ligase III (short-patch)
DNA ligase I (long-patch)
  Nucleotide excision repair DNA ligase III (constitutive)
DNA ligase I (long-patch)
  Single-strand break repair DNA ligase III (short-patch)
DNA ligase I (long-patch)
  Homology-mediated double-strand break repair Unknown
  Non-homologous end joining double-strand break repair DNA ligase IV
DNA ligase III (alternative)
DNA ligase I (alternative)
Mitochondrial DNA metabolism
  DNA replication DNA ligase III
  DNA repair DNA ligase III