Table 3. Prospective associations of circulating inflammatory markers (CRP and IL-6) at baseline with fatigue at follow-up.

Adjustment*	CRP as predictor			IL-6 as predictor
	N	β	P	N	β	P
Age, sex, ethnicity (Model A)	6658	−0.052	<0.001	6614	−0.042	0.001
A + Socioeconomic position	6654	−0.052	<0.001	6610	−0.042	0.001
A + Biomedical factors	6600	−0.033	0.011	6559	−0.031	0.013
A + Health-related behaviors	6532	−0.047	<0.001	6488	−0.035	0.005
A + Fatigue-related symptoms	6649	−0.046	<0.001	6605	−0.039	0.001
Fully adjusted	6465	−0.025	0.048	6424	−0.025	0.044

CRP = C-reactive protein; IL-6 = interleukin-6; β = standardized regression coefficient expressing the change in standardized fatigue score per one standard deviation in log-transformed CRP or IL-6 concentration

^*Biomedical factors include body mass index, systolic blood pressure, presence of common medical conditions, and use of prescription medications that could affect systemic inflammatory status. Health-related behaviors include smoking and alcohol consumption. Fatigue-related symptoms include symptoms of depression/anxiety and sleep difficulty at baseline.