Figure 4. Secondary reduction of biglycan at the basal lamina of UCMD patients.

The integrity of the basal lamina and the reduction of biglycan was further studied using confocal microscopy. An example for UCMD patient 6 at two different magnifications is shown. Arrows point to representative areas where biglycan (A, D, G) appears reduced relative to perlecan (B, E, H). Scale bar: 50 µm.