Table 3.
Human leukocyte antigen distribution, Marsh classification in celiac disease patients n (%)
| tTGA < 100 U/mL (n = 34) | tTGA ≥ 100 U/mL (n = 82) | P value | |
| HLA-score | |||
| 1 heterodimer | 21 (61.8) | 26 (31.7) | |
| 2 heterodimers | 2 (5.9) | 20 (24.4) | 0.005 |
| 4 heterodimers | 11 (32.4) | 36 (43.9) | |
| Marsh classification | < 0.001 | ||
| Marsh IIIa | 5 (14.7) | 4 (4.9) | |
| Marsh IIIb | 22 (64.7) | 18 (22.0) | |
| Marsh IIIc | 7 (20.6) | 60 (73.2) | |
| n = 331 | n = 731 | < 0.001 | |
| Patchy lesions2 | 14 (42.4) | 5 (6.8) |
1
Only 106 patients out of the total study population also underwent duodenal bulb biopsies;
2
Discrepancy in the diagnosis based on histology in the duodenal bulb vs in the distal duodenum. HLA: Human leukocyte antigen; tTGA: Anti-tissue transglutaminase antibodies.