Supplementary Fig. 1.

Funnel plots for 10 commonly reported side-effects. The y axis for all plots is the log odds ratio of a treatment effect (i.e. beta-blocker causing symptom to the right, alleviating symptom to the left), with the dark line the overall log odds ratio. The x axis is the standard error as a measure of the sample size. For most of these side-effects there is spread of values to either side of the overall log odds ratio, with smaller studies (larger standard error) generally diverging furthest from the overall log odds ratio, which does not suggest publication bias.