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. 2013 Oct;15(10):1184–1195. doi: 10.1593/neo.131368

Figure 1.

Figure 1

PFTS inhibits pancreatic cancer growth in vitro. (A) Chemical structure of PFTS (MDC-1016). (B) PFTS inhibits pancreatic cancer cell growth in a concentration-dependent manner. Cell growth was determined in AsPC-1, CFPAC-1, Capan-2, Panc-1, and MIA PaCa-2 after treatment with escalating concentrations of PFTS for 24 hours. Results are expressed as percentage of control. (C) PFTS inhibits MIA PaCa-2 cell growth more potently than FTS. Cell growth was determined in MIA PaCa-2 after treatment with escalating concentrations of PFTS or FTS for 72 hours. Results are expressed as percentage of control. (D) PFTS inhibits pancreatic cancer cell colony formation in a concentration-dependent manner. FTS (20 µM) led to a 42% and 38% inhibition in colony formation in MIA PaCa-2 and BxPC-3 cells.