Table 3.
Multivariate Cox-regression analysis for RFS and EFS in patients with BCP-ALL (N = 164)
| Variable |
Multivariable analysis for RFS |
Multivariable analysis for EFS |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p * | HR | 95% CI | p * | |
| Age |
|
|
|
|
|
|
| <10 |
1 |
Reference |
- |
1 |
Reference |
- |
| ≥10 |
0.239 |
0.023-2.518 |
0.847 |
0.300 |
0.036-2.466 |
0.244 |
| WBC (109/L) |
|
|
|
|
|
|
| <50 |
1 |
Reference |
- |
1 |
Reference |
- |
| ≥50 |
4.677 |
1.715-12.760 |
0.003 |
3.745 |
1.062-13.204 |
0.072 |
|
BCR-ABL |
|
|
|
|
|
|
| Negative |
1 |
Reference |
- |
1 |
Reference |
- |
| Positive |
7.190 |
2.022-25.567 |
0.118 |
2.701 |
0.497-14.681 |
0.250 |
|
TEL-AML1 |
|
|
|
|
|
|
| Negative |
1 |
Reference |
- |
1 |
Reference |
- |
| Positive |
0.508 |
0.057-4.550 |
0.104 |
0.316 |
0.038-2.629 |
0.059 |
|
E2A-PBX1 |
|
|
|
|
|
|
| Negative |
|
|
|
|
|
|
| Positive |
1 |
Reference |
- |
1 |
Reference |
- |
| 7.557 |
1.416-40.334 |
0.257 |
3.890 |
0.877-17.248 |
0.222 |
|
| CNS involvement |
|
|
|
|
|
|
| Absent |
1 |
Reference |
- |
1 |
Reference |
- |
| Present |
25.259 |
5.124-124.504 |
0.001 |
11.375 |
1.487-86.991 |
0.019 |
| rs1544105 |
|
|
|
|
|
|
| CT + TT |
1 |
Reference |
- |
1 |
Reference |
- |
| CC | 4.992 | 1.550-16.078 | 0.007 | 2.723 | 0.766-9.674 | 0.059 |
*Data were calculated by Cox-regression analysis. BCP-ALL, B-cell precursor ALL; RFS, relapse free survival; EFS, event free survival; WBC, white blood cell count; CNS, central nervous system; HR, hazard ratio; 95% CI, 95% confidence interval.