Table 2.
Genotype distribution of the selected SNPs in the study participants (Part 1/2)
|
Selected SNP |
Genotype distribution* |
p for difference | |||
|---|---|---|---|---|---|
| SNP (ID) | Genotype | PTB patients, n (%) | LTBI controls n (%) | Healthy controls without MTB infection n (%) | |
|
IL1RN |
TT |
170 (85.0) |
169 (85.8) |
173 (88.3) |
0.607§ |
| 9589 A/T |
TA |
29 (14.5) |
28 (14.2) |
23 (11.7) |
0.432& |
| (rs454078) |
AA |
1 (0.5) |
0 |
0 |
|
|
IL1B |
CC |
54 (27.0) |
63 (32.0) |
59 (30.1) |
0.270§ |
| -511 C/T |
CT |
96 (48.0) |
97 (49.2) |
99 (50.5) |
0.393& |
| (rs16944) |
TT |
50 (25.0) |
37 (18.8) |
38 (19.4) |
|
|
IL2 |
TT |
89 (44.5) |
90 (45.7) |
87 (44.4) |
0.972§ |
| -330 T/G |
TG |
88 (44.0) |
85 (43.2) |
88 (44.9) |
0.964& |
| (rs2069762) |
GG |
23 (11.5) |
22 (11.2) |
21 (10.7) |
|
|
IL4 |
TT |
120 (60.0) |
106 (53.8) |
105 (53.6) |
0.456§ |
| -589 C/T |
TC |
70 (35.0) |
79 (40.1) |
77 (39.3) |
0.375& |
| (rs2243250) |
CC |
10 (5.0) |
12 (6.1) |
14 (7.1) |
|
|
IL8 |
AA |
74 (37.0) |
75 (38.1) |
68 (34.7) |
0.967§ |
| -251 T/A |
AT |
97 (48.5) |
93 (47.2) |
99 (50.5) |
0.890& |
| (rs4073) |
TT |
29 (14.5) |
29 (14.7) |
29 (14.8) |
|
|
IL8RB |
TT |
83 (41.5) |
83 (42.1) |
78 (39.8) |
0.985§ |
| 1208 C/T |
TC |
85 (42.5) |
82 (41.6) |
88 (44.9) |
0.891& |
| (rs1126579) |
CC |
32 (16.0) |
32 (16.2) |
30 (15.3) |
|
|
IL10 |
TT |
99 (49.5) |
83 (42.1) |
81 (41.3) |
0.282§ |
| -819 T/C |
TC |
80 (40.0) |
94 (47.7) |
87 (44.4) |
0.217& |
| (rs1800871) |
CC |
21 (10.5) |
20 (10.2) |
28 (14.3) |
|
|
IL10 |
TT |
176 (88.0) |
162 (82.2) |
160 (81.6) |
0.133§ |
| -1082 A/G |
TC |
23 (11.5) |
35 (17.8) |
35 (17.9) |
0.201& |
| (rs1800896) |
CC |
1 (0.5) |
0 |
1 (0.5) |
|
|
IL18 |
CC |
157 (78.5) |
147 (74.6) |
152 (77.6) |
0.648§ |
| -137 G/C |
CG |
40 (20.0) |
46 (23.4) |
42 (21.4) |
0.865& |
| (rs187238) |
GG |
3 (1.5) |
4 (2.0) |
2 (1.0) |
|
|
IL18 |
CC |
58 (29.0) |
50 (25.4) |
49 (25.0) |
0.708§ |
| -607 A/C |
CA |
99 (49.5) |
101 (51.3) |
101 (51.5) |
0.658& |
| (rs1946518) |
AA |
43 (21.5) |
46 (23.4) |
46 (23.5) |
|
|
TLR1 |
GG |
90 (45.2) |
90 (35.4) |
74 (37.8) |
0.325§ |
| -7202 A/G |
GA |
84 (42.2) |
91 (32.7) |
103 (52.6) |
0.117& |
| (rs5743551) |
AA |
25 (12.6) |
16 (8.1) |
19 (9.7) |
|
|
TLR2 |
TT |
97 (48.5) |
102 (51.8) |
97 (49.5) |
0.657§ |
| 597 C/T |
TC |
83 (41.5) |
73 (37.1) |
81 (41.3) |
0.956& |
| (rs3804099) |
CC |
20 (10.0) |
22 (11.2) |
18 (9.2) |
|
|
TLR5 |
CC |
189 (94.5) |
189 (95.9) |
188 (96.4) |
0.502§ |
| 1174 C/T |
CT |
11 (5.5) |
8 (4.1) |
7 (3.6) |
0.377& |
| (rs5744168) |
TT |
0 |
0 |
0 |
|
|
TLR9 |
AA |
70 (35.0) |
67 (34.0) |
68 (34.7) |
0.051§ |
| 1174 A/G |
AG |
89 (44.5) |
106 (53.8) |
95 (48.5) |
0.592& |
| (rs352139) |
GG |
41 (20.5) |
24 (12.2) |
33 (16.8) |
|
|
TLR9 |
GG |
72 (36.0) |
70 (35.5) |
71 (36.2) |
0.052§ |
| 1635 A/G |
GA |
88 (44.0) |
104 (52.8) |
93 (47.5) |
0.608& |
| (rs352140) | AA | 40 (20.0) | 23 (11.7) | 32 (16.3) | |
Abbreviations: IL interleukin, IL1RN inteleukin 1 receptor antagonist; IL8RB interleukin 8 receptor beta; LTBI latent M. tuberculosis infection; MTB Mycobacterium tuberculosis, PTB pulmonary tuberculosis, SNP single nucleotide polymorphism, TB tuberculosis, TLR Toll-like receptor.
*Sum may not always add up to total because of missing data.
§p for difference between PTB patients and LTBI controls.
&p for difference between PTB patients and Healthy controls without MTB infection.