Table 3.
Genotype distribution of the selected SNPs in the study participants (Part 2/2)
|
Selected SNP |
Genotype distribution* |
p for difference | |||
|---|---|---|---|---|---|
| Gene | SNP (ID) | PTB patients, n (%) | LTBI controls n (%) | Healthy controls without MTB infection n (%) | |
|
CCR2 |
GG |
125 (62.5) |
125 (63.5) |
120 (61.2) |
0.397§ |
| 190 A/G |
GA |
62 (31.0) |
65 (33.0) |
67 (34.2) |
0.612& |
| (rs1799864) |
AA |
13 (6.5) |
7 (3.6) |
9 (4.6) |
|
|
CCR5 |
GG |
71 (35.5) |
62 (31.5) |
59 (30.1) |
0.511§ |
| 59029 A/G |
GA |
97 (48.5) |
107 (54.3) |
102 (52.0) |
0.515& |
| (rs1799987) |
AA |
32 (16.0) |
28 (14.2) |
35 (17.9) |
|
|
RANTES |
GG |
77 (38.5) |
63 (32.0) |
74 (37.8) |
0.349§ |
| -403 G/A |
GA |
96 (48.0) |
101 (51.3) |
95 (48.5) |
0.988& |
| (rs2107538) |
AA |
27 (13.5) |
33 (16.8) |
27 (13.8) |
|
|
MCP1 |
GG |
71 (35.5) |
64 (32.5) |
75 (38.3) |
0.632§ |
| 2518 A/G |
GA |
96 (48.0) |
104 (52.8) |
88 (44.9) |
0.812& |
| (rs1024611) |
AA |
33 (16.5) |
29 (14.7) |
33 (16.8) |
|
|
NRAMP1 |
GG |
151 (75.5) |
151 (76.7) |
139 (70.9) |
0.837§ |
| D543N |
GA |
47 (23.5) |
43 (21.8) |
55 (28.1) |
0.582& |
| (rs17235409) |
AA |
2 (1.0) |
3 (1.5) |
2 (1.0) |
|
|
P2X7 |
AA |
116 (58.0) |
113 (57.4) |
109 (55.6) |
0.502§ |
| 1513 A/C |
AC |
76 (38.0) |
71 (36.0) |
76 (38.8) |
0.722& |
| (rs3751143) |
CC |
8 (4.0) |
13 (6.6) |
11 (5.6) |
|
|
P2X7 |
CC |
92 (46.2) |
86 (43.7) |
86 (43.9) |
0.835§ |
| -762 T/C |
CT |
81 (40.7) |
86 (43.7) |
88 (44.9) |
0.669& |
| (rs2393799) |
TT |
26 (13.1) |
25 (12.7) |
22 (11.2) |
|
|
TNF-α |
GG |
169 (84.5) |
178 (90.4) |
176 (89.8) |
0.210§ |
| -308 G/A |
GA |
29 (14.5) |
18 (9.1) |
19 (9.7) |
0.284& |
| (rs1800629) |
AA |
=2 (1.0) |
1 (0.5) |
1 (0.5) |
|
|
IFNG |
AA |
74 (37.0) |
57 (28.9) |
73 (37.2) |
0.119§ |
| 2109 G/A |
AG |
97 (48.5) |
99 (50.3) |
85 (43.4) |
0.374& |
| (rs1861494) |
GG |
29 (14.5) |
41 (20.8) |
38 (19.4) |
|
|
CD4 |
CC |
188 (94.0) |
185 (93.9) |
184 (93.9) |
0.593§ |
| 868 C/T |
CT |
11 (5.5) |
12 (6.1) |
12 (6.1) |
0.593& |
| (rs28919570) |
TT |
1 (0.5) |
0 |
0 |
|
|
CD14 |
TT |
54 (27.1) |
66 (33.5) |
60 (30.6) |
0.331§ |
| 159 C/T |
TC |
103 (51.7) |
97 (49.2) |
104 (53.1) |
0.438& |
| (rs2569190) |
CC |
42 (21.1) |
34 (17.3) |
32 (16.3) |
|
|
MBL |
CC |
150 (75.0) |
150 (76.1) |
141 (71.9) |
0.964§ |
| -221 G/C |
CG |
48 (24.0) |
45 (22.8) |
52 (26.5) |
0.742& |
| (rs7096206) |
GG |
2 (1.0) |
2 (1.0) |
3 (1.5) |
|
|
TIRAP |
CC |
196 (98.0) |
190 (96.5) |
188 (96.4) |
0.346§ |
| 539 C/T |
CT |
4 (2.0) |
7 (3.6) |
7 (3.6) |
0.359& |
| (rs8177374) |
TT |
0 |
0 |
0 |
|
|
NFKBIA |
AA |
150 (75.0) |
148 (75.1) |
153 (78.1) |
0.999§ |
| -881 A/G |
AC |
48 (24.0) |
47 (23.8) |
43 (21.9) |
0.322& |
| (rs3138053) |
CC |
2 (1.0) |
2 (1.0) |
0 |
|
|
NFKBIA |
CC |
149 (74.9) |
148 (75.1) |
153 (78.1) |
0.998§ |
| -826 C/T |
CT |
48 (24.1) |
47 (23.8) |
43 (21.9) |
0.316& |
| (rs2233406) | TT | 2 (1.0) | 2 (1.0) | 0 | |
Abbreviations: CD cluster of differentiation, CCR chemokine (C-C motif) receptor, IFKBIA NF-kappa-B inhibitor alpha, IFNG Interferon-gamma, MBL mannose binding lectin, MCP monocyte chemotactic protein, NRAMP natural resistance-associated macrophage protein, LTBI latent M. tuberculosis infection, MTB Mycobacterium tuberculosis, PTB pulmonary tuberculosis, RANTES regulated upon activation, normal T-cell expressed, and secreted, SNP single nucleotide polymorphism, TB tuberculosis, TLR Toll-like receptor, TNF Tumor necrosis factor.
*Sum may not always add up to total because of missing data.
§p for difference between PTB patients and LTBI controls.
&p for difference between PTB patients and Healthy controls without MTB infection.