Table 5.
Combined effect of TLR9 and IFNG SNPs on the development of pulmonary tuberculosis
| TLR9 1174 A/G | IFNG 2109G/A | PTB patients, n (%) | LTBI controls n (%) | Adjusted OR* (95% CI) p value | Adjusted OR & (95% CI) p value | PTB patients, n (%) | Healthy controls without MTB infection n (%) | Adjusted OR* (95% CI) p value | Adjusted OR & (95% CI)p value |
|---|---|---|---|---|---|---|---|---|---|
| AA/AG |
GG/GA |
97 (48.5) |
122 (61.9) |
Ref. |
Ref. |
97 (48.5) |
103 (52.6) |
Ref. |
Ref. |
| AA/AG |
AA |
62 (31.0) |
51 (25.9) |
1.54 (0.97-2.43) p = 0.065 |
1.97 (1.12-3.47) p = 0.019 |
62 (31.0) |
60 (30.6) |
1.10 (0.70-1.73) p = 0.683 |
1.02 (0.59-1.77) p = 0.941 |
| G/G |
GG/GA |
29 (14.5) |
18 (9.1) |
2.04 (1.07-3.91) p = 0.031 |
2.17 (0.96-4.91) p = 0.062 |
29 (14.5) |
20 (10.2) |
1.55 (0.82-2.94) p = 0.178 |
1.41 (0.65-3.08) p = 0.399 |
| G/G |
A/A |
12 (6.0) |
6 (3.1) |
2.53 (0.92-7.00) p = 0.073 |
4.31 (0.21-15.31) p = 0.024 |
12 (6.0) |
13 (6.6) |
0.98 (0.43-2.25) p = 0.965 |
0.95 (0.34-2.62) p = 0.918 |
| p for trend | 0.004 | 0.002 | 0.433 | 0.697 | |||||
Abbreviations: CI confidence interval, LTBI latent M. tuberculosis infection, MTB Mycobacterium tuberculosis, OR odds ratio, PTB pulmonary tuberculosis, SNP single nucleotide polymorphism.
*Partly adjusted for age and gender.
&Fully adjusted for age, gender, education level, income, body mass index, number of BCG vaccination scars and smoking.