Table 5.
Differential expression of genes related to the cell cycle & DNA replication
| Gene ID 1 | Annotation 2 | Mean fold change± SE 3 | Identity 4 |
|---|---|---|---|
| Ssa#S30294618 |
DW581582 |
2.4 ± 0.3 |
Cyclin D1 |
| Ssa#S31971283 |
DY700073 |
2.4 ± 0.2 |
Cell division cycle associated 4 isoform 14 |
| Ssa#S35549130 |
EG835508 |
2.2 ± 0.1 |
Cyclin G2 |
| Ssa#S30291070 |
DW578034 |
−2.0 ± 0.1 |
Cyclin-dependent kinase 2 isoform 1 |
| Ssa#STIR18340 |
TC78544 |
−2.1 ± 0.1 |
Cyclin B1 |
| Omy#S19711047 |
CR367942 |
−2.1 ± 0.2 |
Cyclin B2 |
| Ssa#S35661746 |
EG896464 |
−2.2 ± 0.2 |
Cell cycle progression 1 isoform 2 |
| Ssa#S35547210 |
EG833588 |
−2.2 ± 0.1 |
Mediator of RNA polymerase II transcription subunit 22 |
| Ssa#TC109012 |
TC109012 |
−2.6 ± 0.2 |
Cyclin E1 isoform 1 |
| Ssa#KSS3754 |
NM_001173741 |
−2.8 ± 0.2 |
Minichromosome maintenance complex component 4 |
| Ssa#STIR12008 |
TC69433 |
−3.0 ± 0.1 |
Cell division control protein 2 |
| Ssa#TC103697_S |
TC103697 |
−3.0 ± 0.1 |
DNA replication licensing factor mcm2 |
| Ssa#S30290620 |
DW577584 |
−3.2 ± 0.1 |
Cyclin-dependent kinase 4 |
| Ssa#S35659383 |
EG894101 |
−3.3 ± 0.1 |
Cyclin A2 |
| Ssa#S18888540 |
CB514505 |
−4.2 ± 0.3 |
Minichromosome maintenance complex component 2 |
| Ssa#S35699881 |
EG934599 |
−4.4 ± 0.1 |
Minichromosome maintenance complex component 3 |
| Ssa#S35664683 |
EG899401 |
−4.8 ± 0.4 |
DNA replication complex GINS protein PSF1 |
| Ssa#S30295467 |
DW582431 |
−5.1 ± 0.6 |
Spindle pole body component 24 homolog |
| Ssa#STIR15543 |
TC74419 |
−5.3 ± 0.5 |
Minichromosome maintenance complex component 7 |
| Ssa#S18890448 |
CB516667 |
−6.7 ± 0.6 |
Minichromosome maintenance complex component 5 |
| Ssa#S30277130 |
DW564098 |
−10.6 ± 0.4 |
Cell division cycle associated 7 isoform 1 |
| Omy#S19711255 |
CR367985 |
−14.7 ± 8.7 |
Cyclin E2 |
| Omy#S34311297 | CU069027 | −15.1 ± 2.8 | Cell division cycle 6 protein |
List of selected mRNAs related to the cell cycle & DNA replication found to be increased or decreased in expression in response to rIL-1β stimulation. Genes were assigned to the table based upon both their GO identifier and previous knowledge of their functions. Genes with greatest fold differences in expression are presented, the genes that are lower in expression are denoted by (-) value. The genes shown were significant at p < 0.05 following t- tests with Benjamini-Hochberg FDR and greater than 2-fold change. 1Indicates the unique code for the feature on the microarray, 2Accession number of the cDNA sequence, accession numbers beginning with TC are for oligos from the TIGR Atlantic Salmon Gene Index. 3Fold change, in the case of oligos that featured multiple times in the gene list the one with the highest fold change is reported. 4Identity of the probe target as determined by BLASTX and BLASTN searches.